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Methotrexate is also used to treat certain types of cancer including cancers that begin in the tissues that form around a fertilized egg in the uterus, breast cancer, lung cancer, certain cancers of the head and neck, certain types of lymphoma, and leukemia cancer that begins in the white blood cells .

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in addition, if arava and methotrexate are given concomitantly, acr guidelines for monitoring methotrexate liver toxicity must be followed with alt, ast, and serum albumin testing monthly.
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