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following positive confirmation, this approach was translated to man in order to determine whether the dose of bupropion used in the uk to aid smoking cessation 150mg zyban sustained-release increases extracellular dopamine concentrations in the human striatum.
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bupropion is the same active ingredient that is in zyban.
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these results indicate that, in man, bupropion s therapeutic efficacy is unlikely to principally derive from marked increases in striatal dopaminergic transmission.
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bupropion is both a dopamine reuptake inhibitor and a norepinephrine reuptake inhibitor.
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